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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

social
10.《萤火虫》灵感来自葛底斯堡战役

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

课程安排:周五周六交替上课,入学伊始学员需参加一个为期一周的会议,还有一个为期一周的国际学习研讨会
至少希拉里今年赢得了点什么。我相信她会非常兴奋。

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

From the themed collection: 智能家居变革“从手控到声控”
Open Access Perspective

Soft matter science and the COVID-19 pandemic

v. 使防备,支撑,拉紧,使绷紧

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

除非查尔斯-奥克利成功控诉纽约老板詹姆斯-多兰,尼克斯2016-17赛季唯一的亮点将是克里斯塔普斯-波尔津吉斯在全明星周末斩获技巧挑战赛冠军。

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

Libby把这首歌放在了YouTube频道的评论部分,我把它摘过来了。我将大量的可爱的表述和英式的俚语都用不同颜色区分开了。你能猜出其中的意思吗?“OMG”表带什么意思?
Such claims are unlikely to go away, though. John R. Christy, an atmospheric scientist at the University of Alabama in Huntsville who is known for his skepticism about the seriousness of global warming, pointed out in an interview that 2014 had surpassed the other record-warm years by only a few hundredths of a degree, well within the error margin of global temperature measurements. “Since the end of the 20th century, the temperature hasn’t done much,” Dr. Christy said. “It’s on this kind of warmish plateau.”
Some people remain attached to a theory that can be described as resource scarcity. At its heart this theory suggests that resource development follows a linear pattern in which low-cost resources are developed first, meaning that most if not all future development must be more costly. Unfortunately the history of the industry does not support this view. If anything the experience of the past few decades suggests that the opposite is true.
就目前而言,虽然偶尔出现一些高价交易(比如大新金融中心、以21亿港元售出的太平山顶豪宅),但整个行业弥漫着广泛的悲观情绪。世邦魏理仕数据显示,今年第一季度房地产业最活跃的部分是写字楼,但交易总量也不过8笔。

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

户外空间:从这座露台往下走几步就是一座带有草坪和喷泉、围着围墙的花园。这处房产面积0.10英亩(约405平方米)。
With the release of his book Conscious Capitalism, Whole Foods (WFM, Fortune 500) CEO John Mackey got business leaders thinking about a compelling idea: Companies work best when they create value for all their stakeholders -- not just investors. According to Mackey, key stakeholders include customers, employees, suppliers, society, and the environment. Highlighting companies like Costco, Southwest Airlines (LUV,Fortune 500), and Google (GOOG, Fortune 500), Mackey demonstrates that thinking about more than just the bottom line builds stronger and more efficient businesses.
In P2P lending, borrowers are matched with investors, who are encouraged to put their money into the loans due to higher returns than they could get at state banks.
全球其他地区能加以配合吗?

Graphical abstract: Trends and targets in antiviral phototherapy
From the themed collection: 北京新房将强制上保险
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

先锋(Vanguard)的亚洲投资组合审查主管Yan Pu怀疑,亚洲的产品结构可能阻碍了ETF的发展。例如,亚洲ETF公司提供大量的股票ETF产品,但很少有固定收益产品。她指出,在美国,固定收益ETF增长迅速。

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

Thank you,

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

2.《活力王子》中的王子几乎破产
8. The 2012 Ig Nobel Fluid Dynamics Prize

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

室内环境:这栋房屋在1848年前后建成,上次翻修是在2008年。房屋前门上方有一扇气窗,侧灯的红色玻璃上蚀刻有叶形花纹。屋内一楼有一间带有顶冠装饰板条和两座壁炉的大客厅,其中的一座壁炉给这间正式的餐厅区供暖。客厅外是一间家庭娱乐室,内有凸起的护壁板、一个带有水槽的吧台和另一处餐厅区。那扇法式双开门通往一处铺着石板的露台。有些房间可观赏小纳拉甘西特湾的景观。
为什么我如此有信心东亚不会爆发战争,无论在东中国海还是南中国海?答案很简单,因为我了解推动亚洲变化的力量。虽然许多亚洲邻国会发出愤怒的民族主义声明(他们必须这样做来应对普遍的民族主义情绪),但他们的行动是谨慎和务实的。

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

Still, the optimistic view is that several roadblocks to recovery -- an over-indebted consumer, a moribund housing market and shellshocked banks -- are no longer holding back hiring. Barring an unforeseen shock to the economy, this could mean 2013 will be another year of slow but steady growth.[qh]
The BFC's news has been met with support from people on social media, who have applauded the designers choosing to forgo the use of animal fur.

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

Time Management
4. No talking during the game, wait for half-time or end of the game.
达奇斯说:2011年达美乐的品牌热情大幅度增长,但是2012年无法与之相提并论。他们不能每年都重新设计食谱,真是太可惜了。
['pr?ut?k?l]

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

在上周二晚上放学后,孙轶潇乘坐电梯回家,可是电梯突然故障停止运行。

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

6.杰克·谢帕德差点在第一集中死去
Release date: Spring 2015

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

据英国《卫报》报道,在去年的伦敦时装周期间,有250名反皮草抗议者,2月份的玛丽卡特兰佐秀场也受到了抗议者激烈的抵制。

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

一个由BuzzFeed News(译者注:类似今日头条的新闻搜集网站)所做的分析揭示了本年度Facebook上流传最广的50条假新闻。他们加起来大约有2150万次的点赞、评论及分享。在这些新闻里,23条和美国政治相关,2条关于女人用她们的阴道作为谋杀用的凶器,还有1条关于一个小丑娃娃其实一直都是个真人。

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

According to the country's film regulator, China's box office sales have boosted a whopping 48.7 percent in the last year alone.
Then there were these cautionary tales, where a candidate
'He does smoke cigarettes, he smokes many, many cigarettes.
源于:muscle(n 肌肉)

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

排名:第二
"He (Premier Wen) underlined that China effectively countered the severe impact of the global financial crisis and has maintained steady and fast economic development. This allowed China to become the second-largest economy, almost doubling its GDP in five years."
单词circulation 联想记忆:
Upon downloading WeChat, users are prompted to register either using their QQ accounts or their cell phone numbers. The application then helps users populate their contact lists using existing entries in their cell phone address books. To communicate, users can upload any photo or video on their device, take new ones, or press a button to save a voice message that is transferred almost instantaneously. Voice messages are played back with short beeps at the end to imitate the feeling of instant connection, similar to a two-way radio.
But most overseas islands are sold as freehold properties.

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

今年时装周预计在今年9月14日至18日举行,在此之前,由歌手帕洛玛费斯撰写并由善待动物组织出版的公开信中呼吁伦敦时装周和英国时装协会禁止动物皮草的使用。
China is now home to over 80,000 trade markets and total retail sales of consumer goods would reach 30 trillion yuan this year with consumption contributing to about 60 percent of total GDP growth, Gao said.

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

The show airs on CBS December 4.

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
From the themed collection: 保温材料行业走向绿色是必然趋势
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

但经济学家总体上预计,一旦飓风造成的失真消失,前段时间的趋势就有望恢复并延续。接受《华尔街日报》最新月度调查的45位经济学家预计,到明年6月,失业率将降至7.8%,2013年年底将降至7.5%。部分经济学家说,就业增长可能会摆脱现在的缓慢速度而加快。信安环球投资有限公司(Principal Global Investors)经济学家鲍尔(Bob Baur)说,我觉得到时候企业将必须招人。[qh]

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

36岁的阿德里亚娜·利马排在第四位,其收入为1050万美元,初为人母的罗西·亨廷顿-怀特利(950万美元)与25岁的卡莉·克劳斯(900万美元)分别位列榜单的第六位和第七位。
Deadpool will release on February 12, 2016 and it looks like it's going to be a hilarious movie. Oh yes, there's going to be plenty of action and killing as well.
感谢和凯尔特人的选秀权交换,他们没有理由摆烂。他们或许会从参选球员中选到一个最佳安慰奖以推动球队前行。
New Year comes but once a year. But when it comes it brings good cheer.新年一年只有一次,但每次来临都带来喜悦。

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

Did you write The Lego Batman Movie off as kids-only? Biggest mistake ever. This movie is a witty feat of hilarity, full of dry humor and moments of comedy gold. Basically, if you like Will Arnett in Arrested Development, you will like this.
rid笑+ic+ulous多…的→多笑的→可笑的
1995年,荷兰维和部队未能阻止波黑塞族军队在位于波黑东部的斯雷布雷尼察杀害8000名穆斯林男子和男孩。
好市多首席执行官克雷格杰利内克

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
From the themed collection: 深圳加快建立多主体住房供应体系
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

国际机器人联合会主席Junji Tsuda在他的《全球工业机器人市场》报告中指出,在2017年,全球约有38.7万台工业机器人售出,同比增长31%,创造了500亿美元的收入,而中国则是这一强劲增长背后的关键驱动因素之一。
The gig economy

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

Lighting is key when it comes to getting work done. Instead of investing in your typical, boring college dorm room desk lamp, pick something with a prettier design. Check out vintage stores for one-of-a-kind table lamps or keep it cheap with the Tiffany Table Lamp, $99.99, at Target.com.
Sliced into eight pieces, the pizza works out to $250 per slice, meaning it costs roughly $50 per bite.
The ranking is in part based on how successful alumni have been in their careers, as reflected in the salary data.
瑞士洛桑国际管理发展学院(IMD)和西班牙Iese商学院(Iese Business School)稳坐英国《金融时报》两份高管教育榜单榜首。英国《金融时报》2017年高管教育排行榜开放招生课程和定制课程两份排名的头两名,均由这两所学校包揽。
这之后,场均进球数一直在下滑。2010年南非世界杯上,这一数目跌至2.27个,仅次于1990年意大利世界杯的2.2个。

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
From the themed collection: 北京通州启动群租房专项治理
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

中公教育表示,周二报名的岗位中最抢手的是位于北京的中国就业培训技术指导中心的职位,已有1430人报考了该职位。
与无锡接近的涨幅第二的城市是湖南省省会长沙,该市环比涨幅为4.5%。
开发商:Dontnod Entertainment、Square Enix

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

sur下面+rog要求…要求做下去…代理+ate表名词,“人或地位”→代理人,代替品
而相对来说,普遍推出的新限购政策,并未让其他许多最近几个月表现突出的城市受到影响,房价同比依然大幅上涨。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

After an investigation, Rongchang police arrested Zhou on April 29 for endangering public security, according to the Chongqing Morning Post.
confident
“伦敦商学院拥有优秀的学员群体,国籍非常多样化,具有竞争力和聪明才智,”一位2012级的美国毕业学员评论道:“它也给了我无需参加单纯聚焦美国的美国MBA课程就能(通过交换)在美国学习的机会。”

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

OUTDOOR SPACE: Steps down from the patio is a walled garden with a lawn and a fountain. The property is 0.10 acre.
11月,由财新网(Caixin)赞助的中国制造业采购经理人指数(PMI)初值为48.6,高于预期的48.3。而10月份该读数则为48.3。读数显示上个月中国制造业活动在继续放缓,不过情况没有10月份那么糟糕。
《深红报》称,此次被取消入学资格的学生所在的私人脸书群组名为“哈佛饥渴猥琐资产阶级少年”。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

Some of them still give high return to their shareholders. China Merchants Bank is generous; its dividend reached 30.16% of its net profits.

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

With the right tools in place, you’ll find yourself more productive and efficient.

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

dis离开,course跑,课程-离开课程需要毕业演讲
荷兰合作银行是面向全球农户和农业企业的领先融资机构。

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
From the themed collection: 家居名牌产品登年度“黑榜”
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

至于英国,官方虚构数据同样盛行。英国国家统计局(Office For National Statistics)周二公布,以由来已久的零售价格指数(RPI)衡量,去年12月英国通胀率上升至4.1%。该数字纯属胡扯,英国国家统计局对此心知肚明。该机构告诉人们RPI“没有达到规定标准”,不能作为合格的通胀指标,但自2012年以来该机构一直拒绝采取措施来改善该指标并使之贴近3%的整体通胀率。
Anti-dumping cases were much easier to bring in the US than in the EU where companies first had to pass a public interest test.
Edgar Wright’s Baby Driver is one of the most entertaining thrill rides of this year, this decade. This century.
综合考虑,这些事实与战略规划凸显了中国航天工业的认知——为了成为有竞争力的全球飞机制造商,中国需要拓宽行业的广度与深度。在他们掌握了价值链的两端——飞机设计与集成组装后,中国意识到长期处于价值链中游的组装和子系统地位将摧毁他们的航空业。这就是为什么中国雄心勃勃地与波音、空客等飞机制造商以及美国通用电气公司、劳斯莱斯等发动制造商竞争,形式前所未有地激烈。

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

该项目在毕业3年后的职业晋升方面排名第二。Tiemba项目的毕业生数量迄今只有约250人,使他们成为一个精英团体。
然而,007系列电影主题曲却并没有人们想象的那么历史悠久。第一部《诺博士》和第二部《俄罗斯之恋》没有开场曲,而是安排了管弦乐。《诺博士》甚至插入了《三只瞎老鼠》的怪异演奏。随后,《女王密使》才开始有了开场曲,并且在影片的中间和结尾插入了主题曲。

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

slew
The Bulls get the Kings' pick if it falls outside the top 10, so it's better for the Kings to be a bottom-10 team than to just miss the playoffs in terms of team-building.

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
From the themed collection: 标准变严格倒逼家具行业洗牌
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

Gisele, 37, came in second place, having earned $17.5 million, marking the first year she has not headed up the line-up since 2002.

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
From the themed collection: 广东质监局将抽检智能洁具产品
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

“…called the interviewer by the wrong name.”
“它说明人们看重个人经验,胜过其他可用信息,”库迪斯表示。人们离一个重要事件的中心越远,此事对他们的风险胃口影响就越小。
The TV drama is not based on a novel but the story of a real businesswoman Zhou Ying. Born in the Qing Dynasty (1644-1911), Zhou was the richest female entrepreneur in Shaanxi province at that time.
Columbus Day became a U.S. holiday in 1971. It is generally observed by banks, state government offices, the Postal Service and federal agencies. The bond markets are closed for the holiday, but many businesses and stock exchanges remain open.

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

On Thursday it published its mascot for 2016, the Year of the Monkey, and instantly it became a hit on the Internet; unfortunately some people deemed it "very ugly".
戈尔迪·霍恩(Goldie Hawn)曾因影片《仙人掌花》(Cactus Flower)获最佳女配角奖,她的奖杯坐落在一个非常富有禅宗气息的地方——她的“印度房间”,她常在这里冥想。她的小金人并不是唯一一个和主人有共鸣的奖杯,罗素-克洛(Russell Crowe)曾在影片《角斗士》(Gladiator)中身着罗马战士裙装,扮演了一个威猛、极具感情和个性的古罗马战士--司令官马克西姆斯,他的奖杯放在鸡舍中,因为克洛相信小金人能够保佑母鸡下出更大的鸡蛋。

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

AIj|MhT7HH]
你的阑尾终究可能不是一个无用的进化副产物。你的阑尾不像智齿那样,事实上它可能发挥着重要的生物学功能,恰好现在人类还没准备好放弃阑尾的这种功能。
Tiemba项目在国际化体验方面得分很高,它的一半课程在北京的清华大学校园内完成,另一半在欧洲工商管理学院位于新加坡、法国和阿拉伯联合酋长国(UAE)的三个校区进行。

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

在其他杯赛中,尽管没有做调查,但同样也呈现出类似趋势。
Cnzz.com的报告说,目前中国3.38亿网民中有将近三分之二都是网络游戏玩家。报告说,中国网络游戏行业目前占据了互联网经济总规模的半数以上,在未来还将以每年20%的速度增长。
The values of the citizenry are a democracy’s most important asset.

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

《飞马》
pr(iHbd+xg|gPd&q+&+Y

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

The dumbest 'smart' objects of 2016
Successful CEOs tend to follow a structured, daily schedule of rising early, exercising, having snacks on hand for fuel and socializing many evenings of the week.
Two-thirds of this year’s deals are trading above their issue price. On average, 2017’s class of US IPOs have risen in value by about double the S&P 500, at 20 per cent, according to Renaissance Capital, which runs IPO-focused exchange traded funds.

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

Google and Amazon rank second and third respectively.
死亡可能隐藏在评论人的十大清单这一仪式之后,也包括实体媒体的死亡:清单在手机上更容易读,就算娱乐媒体的泛滥,已经令深刻的阅读近乎不可能实现。截止到年底,纽约今年一共上映了900多部电影,很多影片都在影院内匆匆来去,由于缺乏观众而被遗忘。尽管如此,这一年里,我看了几百部影片,喜欢其中的一部分;不出所料,大制片公司和独立公司都有垃圾制作,但和往常一样,也不乏有价值的作品。下面是我在2015年最喜欢的影片,以及今年的十则杂记。

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

For co-founder Harper, a top priority for the next 12 months is shoring up Bigcommerce’s internal technical talent and creating services that help merchants build closer customer relationships. One example is offering data that helps store managers track “abandoned carts” and offer deals that help turn browsers into buyers. This can help merchants quickly add 15% to their monthly sales, he said.
On Turkey, which recently shot down a Russian warplane, Putin said he sees no possibility of overcoming the strained ties with the current Turkish leadership. He said he was shocked to see that Turkey hadn't tried to explain its action but turned to help from NATO instead.
To be sure, that excitement can certainly lead to unrealistic declarations from those in the community. Some bitcoin developers and investors proclaim that within five years, all the major banks will be accepting bitcoin. That’s a stretch, acknowledges Peter Smith, COO of the bitcoin wallet Blockchain (not to be confused with the actual bitcoin block chain). “I hear a lot of predictions about how soon the whole world will be using bitcoin, and most of the time, those are unrealistic,” he says. “What we’re trying to do as an ecosystem is incredibly audacious, so it’s going to take a lot of time.”

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

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Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
From the themed collection: 进一步完善三地协同政策评价体系
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

productive
摩根士丹利首席执行长戈尔曼(James Gorman)将给该行所谓“降低风险”的策略来个大掉头。

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

泰勒·斯威夫特vs. 凯蒂·佩里
TAXES: Approximately $18,036 a year

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
From the themed collection: 4月 新房断供二手房企稳
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

节目31 京剧《迎来春色换人间》,于魁智 托马斯(孔子学院学员)
"People should just never walk away and leave their animals," Ms Lewis said. "Everyone has a legal obligation to look after animals in their care."

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

A Larger Profile
近些年来,细菌感染卷土重来,受害者达到了自1960s以来从所未见的最高值,初步确诊者的人数从429跃升至1300多人,从2011年到2017年期间的感染人数翻了两倍不止。

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

单词conservative 联想记忆:

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

n. 元素,成分,组成部分,(复数)恶劣天气
n. 外表,外貌,出现,出场,露面
所有外出务工人员的年收入据估计达到了3万亿美元,然而大约有85%仍留在雇主国,他们汇款回家的钱,平均不到雇主国GDP的百分之一。
Rouslan Krechetnikov和Hans Mayer对液体的溅出现象进行了研究。他们考察的课题是:人们在端着咖啡杯走动时咖啡的溅出情况,给你个提示吧,在你走到第七步至第十步之间,咖啡最容易溅出。

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

据张晓光表示,怀旧部分将包括出自上海文华电影制作工作室的电影,该公司成立于1946年、引领了中国文艺电影的新时代,将会让观众“一睹中国的电影文化和历史”。

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

[ju:'ni:k]
Extreme heat blanketed Alaska and much of the western United States last year. Records were set across large areas of every inhabited continent. And the ocean surface was unusually warm virtually everywhere except near Antarctica, the scientists said, providing the energy that fueled damaging Pacific storms.
In the foreseeable future, China will see the boom of enterprises in tertiary industry. Related majors, including law, journalism and communication, and management, are expected to play a bigger role, according to the report.

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
From the themed collection: 警惕新一轮房价上涨
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

They say that it is especially risky to use the same password for entertainment sites as for email and social networking accounts.
n. 失业,失业人数

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

“We will see a lot of headlines about [emerging market export growth] picking up in the first half of 2017,” says Bhanu Baweja, head of EM cross asset strategy at UBS, who believes EM exports will show year-on-year growth of between 8 and 13 per cent in dollar terms in the first quarter of this year, “a complete postcode away” from the negative numbers currently being reported.
首次发现直接由禽类传染人类的流感病毒,此病毒的传染与接触家禽市场有关。香港有六人死亡。这种病毒之所以不同,是因为它并没有通过传染猪,使猪成为中间宿主,而是直接由鸡传染给人类。另外,年轻人中感染最严重的病症有些与1918年“西班牙流感”病毒相似。

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

007系列电影主题曲第九名:露露--《金枪人》

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
From the themed collection: 新华社:房企违规将列入黑名单
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

无论是电视剧,还是正在拍摄的电影版本,都是改编自台湾大宇公司旗下著名的角色扮演游戏(RPG)《仙剑奇侠传》系列。这款电子游戏也被许多玩家视为中国最棒的角色扮演游戏。
Those quickly sold out, locking out the vast majority of fans in soccer-mad Brazil.
人们的担忧涵盖了各个领域,从全球问题(比如俄罗斯试图影响2016年美国总统选举),到地方问题(比如担心用户淹没在通知和新闻推送中,造成心理健康问题和生产率损失)。

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

日前,斯坦福大学商学院(Stanford Graduate School of Business)教授彼得o库迪斯基于这场荷兰危机共同撰写了一篇文章,围绕“个人经验(而非市场信息)决定乐观、悲观以及信贷的获得与否”这种不那么科学的方法给出了现代经验。
科派斯塔克说,人们对经济紧缩和欧元稳定的忧虑使得过去一年欧元区城市的生活成本指数降低了,而加拉加斯能跻身前20则是由于人为的高汇率管制。
以美元计算的话,这一跌幅就更加明显了,上个月出口同比下滑11.2%至1774.8亿美元。这一跌幅不仅超过了去年12月1.4%的跌幅,也超过了下滑1.8%的预期。这是自去年3月下滑15%以来的最大跌幅。
6.凡事以人为先

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

总的来说,在选择就读EMBA的原因中,创业排在最末(10分中得5.5分)。学员的主要动机是学习管理(9.1分)、拓宽人脉(8.3分)及增加收入(8.1分)。
英国大选就是个教训。民调也不过是戛纳的“外卖餐点”:预测是傻瓜才干的事。一整周,坊间盛传托德?海因斯的女同性恋恋爱故事《卡罗尔》将斩获金棕榈最佳影片奖,或者拉斯洛?杰莱斯László Nemes 处女作《索尔的儿子》Son of Saul将折桂。最后几天,共识则是来自台湾的导演侯孝贤(Hou Hsiao-Hsien)指导的《刺客聂隐娘》(The Assassin)将问鼎大奖。且据英国博彩分析,《龙虾》是个难缠的对手。但是,最终宣布雅克?欧迪亚Jacques Audiard's 《流浪的迪潘》Dheepan获奖时,大家一致惊讶表示:“真的吗?”所有的评论员、影评人小组、内部八卦、数据统计、上帝都知道,只是少有人提及罢了。好吧,这就是生活。

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
From the themed collection: 前8月全国棚户区改造开工465万套
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

My fellow trainer, Sylvia Guinan, made me aware of these rules that a husband has laid out for his wife to follow during the 2014 World Cup.
“Policymakers around the world are cognisant of the impact the Fed decision will have and are worried, which makes us worried,” said Simon Lue-Fong, head of global emerging debt at Pictet Asset Management. “People are saying the decision is priced in but seeing as no one knows exactly what will happen how can that possibly be true.”
Last year was especially striking because global heat records were broken or tied in every month except January and April, researchers said.

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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Hilcorp Energy
Quanta Computer, ” in October. Samsung is also reported to be working on a 12 to 13-inch tablet, and it seems evident that “these large-size tablets will greatly impact ultrabook demand.” This “iPad Max” will be a defacto laptop with the addition of new cases with integrated keyboards and batteries and could well become a mainstay for high schools and college students who need better content creation tools than thos offers on existing iPads and iPad Minis.

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