Part 2: Health apps, wearables, and sensors: The advancing frontier of digital health

As China's economic structure evolves, the rich list also is changing.
During last year's LFW, there were 250 anti-fur protesters, The Guardian reported, and a show in February saw an activist storm the stage at a Mary Katrantzou show.
去年,中国工商银行的每股盈利为0.77元人民币,低于上一年的0.78元人民币,税前每股分红为0.2333元人民币,低于上一年的0.2554元人民币。
《自己土地上的陌生人: 美国右翼的愤怒与哀悼》(Strangers in Their Own Land: Anger and Mourning on the American Right)一书的作者阿莉?罗素?霍克希尔德(Arlie Russell Hochschild)对路易斯安那州的农村社区进行了四年的研究,她认为那里“深藏着”一种失去机会的感觉。
The deal makes a millionaire of 17-year-old Mr D’Aloisio, who taught himself to write software aged 12 and will join Yahoo’s London office while he continues his studies at school.
Against: It might be that bit too far from the mainstream to make a huge awards impact.
伦敦商学院在所有这4项排名上表现强劲,包括全日制MBA课程排名第一,合办EMBA(与美国哥伦比亚商学院(Columbia Business School)合办)和定制高管教育课程均排名第三。
The potential for conflict will force China and the US to redefine their roles in a shifting environment that neither is comfortable with. Tensions will be aggravated by anti-China sentiment during the American elections. Asian countries are in a position to delineate the boundaries of influence for these two powers but, given their varied interests, alliances will shift depending on individual concerns.
A cheery New Year hold lots of happiness for you!给你特别的祝福,愿新年带给你无边的幸福、如意。
[iks'p?uzd]
We believe our initiative of mass entrepreneurship and innovation is a response to the call of our time, the government self-targeted reform of streamlining administration and delegating power is also to boost this public enthusiasm for business start-ups and making innovations.
Life's ups and downs
达洛伊西奥也尽力维持着生活原本的样子。他的女友还是之前的那个女友。而且尽管他不再去学校了──坐在教室里就没空监管Summly的研发──他还是照常去找老师拿作业。他十分庆幸他的朋友不了解他企业家的那一面。而当我采访他的时候,他正准备和一群高中死党去希腊玩上一周。
Marcos Carvalho, an 18-year-old Brazilian fan who was hanging out near the Estadio Nacional in Brasilia before Brazil played Cameroon earlier this week, said that he "didn't even try getting tickets, they were too expensive.""There was no way we could afford them," he said. "We'll just watch the match at home, it's all we can do. We are seeing everyone going to the stadium, everyone happy, but we won't be going."
在咨询公司Brand Finance的《2017年全球500强》报告中,搜索巨头谷歌超过了iPhone的制造商苹果公司,成为了全世界市值最高的公司。
Callabro,喜欢唱歌剧的男孩组合在经过不懈努力之后成功成为了本年度的英国达人秀冠军,最具天赋的歌唱组合。
In the original casting, Michael Keaton was set to play the character. However, ABC executives begged the writers and producers to keep Jack alive. They believed the character was too likeable to die off so quickly. The writers agreed. Michael Keaton was not interested in signing up for a long-running show. Instead, the role of Jack was given to Matthew Fox. The rest is TV history.
测试采用闭卷形式,长达两个半小时。理论上说,妮诗的测试成绩以及由此推算出的162分智商比大名鼎鼎的物理学家爱因斯坦还要高2分。
That an iPhone mini and a LTE license from the Chinese government this year or next could finally persuade China Mobile (CHL), with 700 million subscribers, to cut a deal with Apple.
The company realised that "it was all a mistake and that he did it without thinking," a Google spokeswoman said last Wednesday.
The ECB ended the year with a vote on December 3 to cut its deposit rate to minus 0.3 per cent and an expansion in asset purchases that leaves its quantitative easing programme at 1.46tn. The move came days before the US Federal Reserve increased interest rates for the first time since 2006, underlining the sharply divergent policies being pursued on either side of the Atlantic.
在几代人之中,工薪阶层的白人受到双重赐福:他们既拥有种族所带来的特权地位,也受惠于经济的繁荣发展。
艾丽斯·斯瓦策尔多年来一直为争取女性权利而斗争。她对像唐纳德·特朗普这样“老式的性别歧视者”能够当上美国总统深感震惊。
n. 临时工
Despite the overall upward trends in financing, the amount of capital raised by women-owned businesses has historically lagged when compared to men. For example, in the first half of 2013, women made up only 16 percent of businesses seeking funding, with only 24 percent of the women receiving angel funding, Plum Alley, an online e-commerce platform for female entrepreneurs, recently launched a crowdfunding platform specifically focused on helping women innovators get to the next level. And as the first platform of its kind in the exploding crowdfunding space (expected to hit $3.98 billion next year), we can certainly expect Plum Alley to play a big role in the entrepreneurial landscape for women in the year to come.


'She enjoys it and we don't force her to do anything she doesn't want to do.'
designated
[slu:]


With the increasing proliferation and sophistication of mobile phones, wearable devices such as smart watches, and sensors that can measure and gather a variety of data, public interest is growing in using consumer electronics to take ownership of personal health and wellness. A 2015 survey found that 66% of Americans age 66 and older want to use mobile technologies to improve their health by receiving medication reminders and tracking diet and nutrition, physical activity, and symptoms.[1

4. HHhH
1月份PPI同比下跌5.3%,跌速比去年12月的负5.9%有所放缓。自2012年3月起,中国PPI一直留在负值区间,去年8月起连续5个月位于负5.9%的低点。
The writer is a senior associate at the Carnegie Endowment and a former World Bank country director for China. Read other predictions for the world economy, politics and finance in 2012 at www.ft.com/thealist
STEP 5: GET RID of most of your friends

Health apps and wearables
Health apps and wearables can unobtrusively gauge physiological and emotional states and collect, quantify, and monitor data regarding a user’s day-to-day behaviors. This “quantified self” can increase users’ self-awareness regarding their behavior and encourage positive changes to their overall health and well-being.[2] These commercially available devices also integrate an array of features to provide motivation through reward systems, opportunities for social in-teraction, tools for self-improvement, and prompts. The novelty, affordability, practicality, and ease of use have resulted in increased consumer enthusiasm and the pervasiveness of these devices.[3,4] With this growing interest in personal health, members of the general public are becoming more involved in monitoring and improving their own health habits.[5-10

Undoubtedly, merely tracking data through a device is not enough to maintain good health-related behaviors long-term, and the software must also incorporate motivational constructs important for the adoption and habituation of behaviors. For instance, a systematic review of studies that considered the use of electronic activity monitor systems found short-term changes in physical activity with self-monitoring, but no demonstration of superiority when the systems were compared with other interventions.[11] Another review of studies on the viability of using mobile technology for measuring and influencing physical activity found that most apps allow users to document their activity, set goals, review real-time feedback, connect to a social support network, and access online expertise.[12] However, less common among these apps were prompts to act and opportunities for problem solving and action planning, which are crucial constructs that translate intention into long-term behavior change.[13]

Sensor technologies
Sensor technologies have begun to enter the telehealth landscape and are primarily focused on continuous monitoring and precise diagnostics to inform management of various health conditions and diseases.[14-17] Sensors can be integrated into a watch or arm band or adhesive bandages and clothing, and then programmed to collect data on cardiac rhythm, heart rate, blood pressure, respiration, oxygen saturation, galvanic skin response, glucose levels, body temperature, body motions, ambient temperature, and global positioning. For health care providers, sensor inputs can permit remote monitoring, real-time teleconferencing, and timely care for patients with chronic diseases. For both patients and clinicians, telehealth supported by sensors can have profound implications. Clinicians can provide timely and patient-centred care to those living at a distance with chronic disease and can coordinate care when multiple providers are involved, reducing costs to the health care system.

A current clinical example is the management of paroxysmal atrial fibrillation with a mobile ECG and app that monitors the patient’s electrical rhythm to detect frequency and patterns of arrhythmias, and may even allow patients to share ultrasound and electrocardiogram data with their health care provider.[18-20] Telemonitoring with sensors can also support self-management of chronic diseases and detect early signs of deterioration in health requiring immediate treatment and advice.[21] Studies to date have demonstrated some clinical promise for the use of home telemonitoring in the context of heart failure and diabetes. A recent Cochrane review found that telemonitoring was an effective way to lower levels of glycated hemoglobin and low-density lipoprotein.[22] Although several studies on heart failure have produced conflicting results regarding the overall benefits of home monitoring,[23-26] systematic reviews have suggested that home telemonitoring reduces all-cause mortality and hospitalizations, and improves quality of life compared with usual care.[22,27] In addition, features such as automated and mobile telemonitoring appear to be more effective compared with other forms of home telemonitoring.[27]

Further studies are needed to determine how home health monitoring can improve patient safety during the transition from acute care to community care, and to examine the impact of home monitoring on health care costs. TEC4Home (Telehealth for Emergency-Community Continuity of Care Connectivity via Home Tele-monitoring), an initiative of the University of British Columbia and Vancouver Coastal Health, is seeking to do this with prospective trials designed to uncover how telemonitoring can support the safety of heart failure patients discharged from hospital to home.[28]

Mobile apps, wearables, and sensors in the clinical setting
Even though mobile apps, wearables, and sensor technologies are promising, further research is needed to validate their use and long-term impact.[29] This research will require the collaboration of clinicians, health researchers, engineers, and computer scientists.[30] Understanding the possible risks of using these technologies, from physiological harm to breaching of privacy and confidentiality with insecure devices, and how to mitigate any risks is also important. Other important issues to consider include patient anxiety with overuse of technologies, health data piracy, self-diagnosis resulting from overreliance on self-monitoring, and patients not seeking help appropriately. These technologies should be used only as complementary tools in the treatment and prevention of health conditions and disease and should not be used in isolation by patients who self-diagnose and self-manage without consulting a health professional. 

人们最为关心的问题是,2015年石油价格将何去何从?石油目前的低价位是不可持续的。许多产油成本较高的企业和地区都处于亏损状态。短期内这种状况也许还可以应付,但中长期来看,石油公司将被迫退出市场,进而带动油价上升。然而,最重要的问题在于:石油价格何时上涨,以及涨幅能有多大?

Instant Heart Rate by Azumio.[31] A free app downloadable to both Apple and Android operating systems that measures heart rate and displays a monitoring strip. As well as helping users accurately track their heart rates, the app is capable of detecting irregular rhythms when palpitations occur. 

Sleep Time by Azumio.[32] A free app that monitors sleep patterns, sleep efficiency, and also acts as an alarm clock. Users can know how often they go into light and deep sleep, and recognize how much of these types of sleep will be necessary for them to feel rested, thereby quantifying the amount of true sleep they need and not just how long they should stay in bed. 

Bellybio Interactive Breating by RelaxLine.[33] A free app that helps users pace their breathing to achieve calmness. Placing the mobile phone against the abdomen, users can follow the sounds emitted to practise deep, abdominal breathing using this simple yet surprisingly effective tool. 

8.出租车司机
由于电影业采取了更为市场化的改革措施,中国的票房总额在过去几十年里从10亿元人民币增长到了400亿元人民币。

The prize sold for a winning bid of $950,000 at auction, and an additional buyer's commission brought the final sale price to $1.16 million.
Bolder lawyers will start working with more “sci-fi” programs that claim to predict the outcomes of legal disputes before they have reached court, by analysing similar cases and past rulings, opposition tactics and win/lose statistics, the success rates of certain lawyers before certain judges, and so on.
眼见克莱斯勒的市场份额呈现死亡式螺旋下降,菲亚特会最终认识到这个不中用的公司还真就是不中用了。预计菲亚特会在8月前扬言彻底和克莱斯勒分道扬镳,除非全美汽车工人联合会(UAW)和美国纳税人作出更多让步。
Hua Xu Yin is about a princess who sacrificed her life for the country but later was saved and began her own adventures with another name. It is also a TV series adaptation of an online novel of the same title written by Tang Qi. The series premiered in July 2015, staring Lin Yuan and Zheng Jiaying. However, it did not get as much attention as its rivals. According to the online critics, the lead roles and their costumes were not appealing enough in the adaptation.
《不可思议的杰西卡?詹姆斯》
现在压力都在诺埃尔这里了,他得证明自己远比在76人时期迷失在混乱中的时候强。

Discernment to determine whether a particular app, wearable, or sensor can be effective.
Expertise and experience to guide patients on the use of technology.
Partnership with patients in pursuit of optimal health through technology use.
Trials to closely monitor benefits and drawbacks.
Humility to recognize that patients may know and invest much more time than physicians in looking for these tools.34

Conclusions
Based on today’s rapid pace of development and public enthusiasm for the technology marketplace, health apps, wearables, and sensors will soon become integral to our patients’ pursuits of good health and will need to be integrated in clinical practice. Physicians must be active agents in these evolutionary times, guiding patients, advocating for evidence to support the use of technologies, and participating in the development and incorporation of technology in patient wellness journeys. Through clinical stewardship and partnership with patients, physicians can use their expertise and experience to guide the growth of innovations into mainstream health care.

Competing interests
Dr Ho receives no personal financial compensation as the principal investigator of TEC4Home (Telehealth for Emergency-Community Continuity of Care Connectivity via Home Tele-monitoring), a project funded by a Canadian Institutes of Health Research grant. This grant is matched by the Michael Smith Foundation for Health Research and the BC Ministry of Health, with additional support provided by TELUS Health and Sentrian. TELUS Health, Cisco, and Avizia have also provided equipment for display in Dr Ho’s Demonstration and Simulation Studio for Health (DaSSH) at UBC. Mr Yao and Dr Lauscher have no competing interests to declare.


(两会受权发布)李克强说,加快发展社会事业,更好保障和改善民生


References

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2. Swan M. Emerging patient-driven health care models: An examination of health social networks, consumer personalized medicine and quantified self-tracking. Int J Environ Res Public Health 2009;6:492-525.

3. Gao Y, Li H, Luo Y. An empirical study of wearable technology acceptance in healthcare. Ind Manag Data Syst 2010;115:1704-1723.

4. Kim KJ, Shin DH. An acceptance model for smart watches: Implications for the adoption of future wearable technology. Internet Res 2015;25:527-541.

5. West JH, Hall PC, Hanson CL, et al. There’s an app for that: Content analysis of paid health and fitness apps. J Med Internet Res 2012;14:e72.

6. Abroms LC, Padmanabhan N, Thaweethai L, Phillips T. iPhone apps for smoking cessation: A content analysis. Am J Prev Med 2011;40:279-285.

7. Cowan LT, Van Wagenen SA, Brown BA, et al. Apps of steel: Are exercise apps providing consumers with realistic expectations? A content analysis of exercise apps for presence of behavior change theory. Health Educ Behav 2013;40:133-139.

8. Azar KM, Lesser LI, Laing BY, et al. Mobile applications for weight management. Am J Prev Med 2013;45:583-589.

9. Breland JY, Yeh VM, Yu J. Adherence to evidence-based guidelines among diabetes self-management apps. Transl Behav Med 2013;3:277-286.

10. Lyons EJ, Lewis ZH, Mayrsohn BG, Rowland JL. Behavior change techniques implemented in electronic lifestyle activity monitors: A systematic content analysis. J Med Internet Res 2014;16:e192.

11. Lewis ZH, Lyons EJ, Jarvis JM, Baillargeon J. Using an electronic activity monitor system as an intervention modality: A systematic review. BMC Public Health 2015;15:585.

12. Bort-Roig J, Gilson ND, Puig-Ribera A, et al. Measuring and influencing physical activity with smartphone technology: A systematic review. Sports Med 2014;44:671-686.

13. Rhodes RE, Yao CA. Models accounting for intention-behavior discordance in the physical activity domain: A user’s guide, content overview, and review of current evidence. Int J Behav Nutr Phys Act 2015;12:1-14.

14. Chen M, Gonzalez S, Vasilakos A, et al. Body area networks: A survey. Mob Networks Appl 2011;16:171-193.

15. Appelboom G, Camacho E, Abraham ME, et al. Smart wearable body sensors for patient self-assessment and monitoring. Arch Public Health 2014;72:28.

16. Chan M, Estève D, Fourniols JY, et al. Smart wearable systems: Current status and future challenges. Artif Intell Med 2012;56:137-156.

17. Alemdar H, Ersoy C. Wireless sensor networks for healthcare: A survey. Comput Networks 2010;54:2688-2710.

18. Haberman ZC, Jahn RT, Bose R, et al. Wireless smartphone ECG enables large-scale screening in diverse populations. J Cardiovasc Electrophysiol 2015;26:520-526.

19. Ferdman DJ, Liberman L, Silver ES. A smartphone application to diagnose the mechanism of pediatric supraventricular tachycardia. Pediatr Cardiol 2015;36:1452-1457.

20. Baquero GA, Banchs JE, Ahmed S, et al. Surface 12 lead electrocardiogram recordings using smart phone technology. J Electrocardiol 2015;48:1-7.

21. Wootton R. Twenty years of telemedicine in chronic disease management—An evidence synthesis. J Telemed Telecare 2012;18:211-220.

22. Flodgren G, Rachas A, Farmer A, et al. Interactive telemedicine: Effects on professional practice and health care outcomes. Cochrane Database System Rev 2015;(9):CD002098.

23. Mortara A, Pinna GD, Johnson P, et al. Home telemonitoring in heart failure patients: The HHH study (Home or Hospital in Heart Failure). Eur J Heart Fail 2009;11:312-318.

24. Dar O, Riley J, Chapman C, et al. A randomized trial of home telemonitoring in a typical elderly heart failure population in North West London: Results of the Home-HF study. Eur J Heart Fail 2009;11:319-325.

25. Chaudhry SI, Mattera JA, Curtis JP, et al. Telemonitoring in patients with heart failure. N Engl J Med 2010;363:2301-2309.

26. Koehler F, Winkler S, Schieber M, et al. Impact of remote telemedical management on mortality and hospitalizations in ambulatory patients with chronic heart failure: The Telemedical Interventional Monitoring in Heart Failure study. Circulation 2011;123:1873-1880.

27. Kitsiou S, Pare G, Jaana M. Effects of home telemonitoring interventions on patients with chronic heart failure: An overview of systematic reviews. J Med Internet Res 2015;17:e63.

28. TEC4Home Healthcare Innovation Community. Supporting heart failure patient transitions from acute to community care with home telemonitoring technology: A protocol for a provincial randomized controlled trial (TEC4Home). JMIR Res Protoc 2016;5:e198. 

29. Yao C, Ho K. Mobile sensors and wearable technologies. In: Amelung VE, Stein V, Goodwin N, et al., editors. Handbook integrated care. Cham, Switzerland: Springer; 2017.

30. Ho K, Borycki E, Kushniruk A, et al. The health perspective in using digital media for health and wellness. Presented at the IEEE International Digital Media Industry Forum, Boston, MA, 4-6 July 2016.

31. Azumio Inc. Instant heart rate. Accessed 28 August 2017. www.azumio.com/s/instantheartrate/index.html. 

32. Azumio Inc. Sleep time. Accessed 28 August 2017. www.azumio.com/s/sleeptime/index.html. 

33. RelaxLine. BellyBio. Accessed 28 August 2017. https://itunes.apple.com/ca/app/bellybio-interactive-breathing/id353763955?mt=8.

34. Ho K. How health information technologies are enhancing health of patients and their doctors. Presentation at the Alberta Medical Association 2015 Spring Representatives Forum, Edmonton, AB, 13 March 2015.


3. Flying Horse
Gurinder Chadha goes colonial with a tale of the 1947 handover and its fallout, when Lord and Lady Mountbatten lived in a mansion also containing 500 Hindu, Muslim and Sikh servants. Hugh Bonneville and Gillian Anderson are our central couple.
“我们从斯雷布雷尼察大屠杀事件了解了荷兰和荷兰人是什么样的,”埃尔多安说起现代荷兰历史上最可耻的一幕,“我们从他们屠杀那里的8000名波斯尼亚人就知道,他们品德败坏到何等地步。”
新美国基金会(New America Foundation)高级研究员李?德鲁特曼(Lee Drutman)在一份给Vox的分析文章中指出,在阿肯色州、北卡罗莱纳州和田纳西州,移民人口是1990年的三倍以上。围绕这些变化产生的焦虑或许可以解释共和党为什么在这个阶段更关注限制移民问题,还有这些州的白人投票者们何以压倒性地支持特朗普。
经理们在公司会管理等级制度上低于他们的人,但是优秀的经理也有方法管理他们的上级和代表团队的同事。很多时候这意味着有效的交流,管理期望和及时寻求帮助。
在星期六晚上他们再次献唱《悲惨世界》原声《Stars》。
位于加州的斯坦福大学商学院(Stanford Graduate School of Business)排名第二,2016年排在第五位,该学院曾在2014年获得亚军。宾夕法尼亚大学沃顿商学院(Wharton School of the University of Pennsylvania)排名第三。
法律
2.Batman vs Superman: Dawn of Justice
科森重塑了卡瑞尔的鼻子,把它变成鹰钩鼻。他还把卡瑞尔的发际线往后刮了一点,留出更多额头。

Kendall Ho, MD, FRCPC, Christopher Yao, MSc, Helen Novak Lauscher, PhD. Part 2: Health apps, wearables, and sensors: The advancing frontier of digital health. BCMJ, Vol. 59, No. 10, December, 2017, Page(s) 503-506 - Clinical Articles.



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Small circulation also contributed to the monkey stamp's record price. Only five million "Golden Monkey" stamps were released for circulation in 1980, and they are exceedingly rare now.
“对新兴市场来说,今年是惨淡的一年,”瑞士基金管理公司GAM的新兴市场投资总监保罗麦克纳马拉(Paul McNamara)表示。“资产不断流失,而没有人肯定下周这个时候市场会是什么样子。”
统计数据显示,在2009年之前,全球研发支出以每年约7%的速度增长,但在2014年放缓了4%。
code

Total migrant worker earnings are estimated to be $3 trillion annually, of which approximately 85 percent remains in the host countries. The money migrants send home averages less than one percent of their host country's gross domestic product, IFAD said.

  • Only the first three authors are listed, followed by "et al."
  • 家居产业(北京)十大品牌景气报告发布
  • 北京首批限房价项目获批入市 短期入市房源有望超2万套


encouragement
考克斯说:“没人真正知道末日是什么样子的,上帝又会如何让末日降临。”

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